근관소독제의 세포독성에 관한 연구
A STUDY ON THE CYTOTOXlClTY OF ROOT CANAL ANTlSEPTlC SOLUTlONS
김재구, 임미경,
소속 상세정보
김재구 ( ) - 원광대학교
임미경 ( ) - 원광대학교
KMID : 0362319930180010095
Abstract
Two functions of root canal medicaments and irrigants are to reduce microorganisms and to encourge the repair of apical tissues.
The biocompatibility of endodontic materials has been tested using in vitro cell culture techniques.
The purpose of this study was to evaluate and compare the cytotoxici effects of 2 root canal irrigation solutions and 4 antiseptics on HEp-2 and McCoy cells.
Two irrigation solutions were sodium hypochlorite, H2O2 and 4 antiseptics were povidone, ethanol, glutaraldehyde and benzalkonium chloride.
Each solutions were serially diluted to 1:1, 1:10, 1:10E2, 1:10E3, 1:10E4, 1:10E5, 1:10E6. And each diluted solutions were added to the cells and cytotoxic effects were measured with the absorbance of formazan formed cells by ELISA READER.
@ES The results were as follows:
@EN 1. Benzalkonium chloride was the most cytotoxic on HEp-2 cell. (P<0.05)
2. H2O2 was the most cytotoxic on McCoy cell. (P<0.05)
3. Povidone and ethanol showed mild cytotoxic effect on HEp-2 and McCoy cell.(P<0.05)
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